abstract：BACKGROUND AND OBJECTIVE:Our objective was to assess the activity of thiopurine methyltransferase (TPMT) in a very large number of Spanish patients with inflammatory bowel disease (IBD), to evaluate the influence of several variables (including azathioprine or 6-mercaptopurine) on that activity, and to know the proport...

journal_title：Medicina clinica

authors： Gisbert JP,Gomollón F,Cara C,Luna M,González-Lama Y,Pajares JM,Maté J,Guijarro LG

更新日期：2005-09-10 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Obesity is associated with cardiovascular risk factors and heart failure. SUBJECTS AND METHOD:Thirty children with overweight or obesity were matched with 30 healthy children. Corrected QT interval (QTc) and QT dispersion (QTd), left ventricular mass, left ventricular mass index, fractional sh...

journal_title：Medicina clinica

authors： Olivares López JL,Vázquez Olivares M,Fleta Zaragozano J,Moreno Aznar LA,Bueno Sánchez M

更新日期：2005-06-18 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Several models for the prediction of liver fibrosis have been developed which consist of the measurement of routine laboratory data: a) a model combining platelets, gamma-glutamil-transpeptidase, cholesterol and age (Forns model), and b) a model using an aspartate-aminotransferase to platelet r...

journal_title：Medicina clinica

authors： Romero Gómez M,Ramírez Martín del Campo M,Otero MA,Vallejo M,Corpas R,Castellano-Megías VM

更新日期：2005-05-28 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Liver re-transplantation (re-LT) is an accepted indication for some (technical problems, primary non-function [PNF]) but not all indications, particularly recurrence of the original disease, such as hepatitis C. We aimed to determine in our center: a) the rate of survival following re-transplan...

journal_title：Medicina clinica

authors： Landaverde C,Berenguer M,Aguilera V,San Juan F,Prieto M,Berenguer J

更新日期：2005-05-21 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The progressive accumulation of iron in the organism contribute to one of the most important problems of morbidity and mortality in patients with myelodysplastic syndrome (MDS). We present an observational protocol, multicentre, open and non-aleatheorised, in patients diagnosed with MDS on tran...

journal_title：Medicina clinica

authors： González FA,Arrizabalaga B,Villegas A,Alonso D,Castro M,Remacha A,del Arco A,Martín Núñez G,Grupo Español de Eritropatología Española de Hematología y Hemoterapia.

更新日期：2005-05-07 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The aim of this prospective randomized trial was to compare the effectiveness and morbidity of surgical vs chemical sphincterotomy in the treatment of chronic anal fissure after a 3-year follow-up period. PATIENTS AND METHOD:Eighty patients with chronic anal fissure were treated either with cl...

journal_title：Medicina clinica

authors： Arroyo Sebastián A,Pérez Vicente F,Miranda Tauler E,Sánchez Romero A,Serrano Paz P,Calpena Rico R

更新日期：2005-04-23 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Our objective was to analyze those factors predisposing to delirium in patients older than 84 years who were admitted because of hip fracture. We also compared the prevalence of delirium in this population with a younger group. PATIENTS AND METHOD:One hundred and thirty patients (mean age 91.8...

journal_title：Medicina clinica

authors： Formiga F,Marcos E,Olmedo C,Ramon JM,López-Soto A,Pujol R

更新日期：2005-04-16 00:00:00

abstract：:In the last years stem cells (SC) have generated huge expectations and have become a new hope for the development of novel cell therapies in the context of regenerative medicine. So far, the hypothetic therapeutic effects of SC, both of embryonic and adult origin, have been demonstrated only in a very few cases. Embry...

journal_title：Medicina clinica

authors： Barquinero J,Pellicer M,Pétriz J

更新日期：2005-04-09 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The management of cardiac ischemic patients differs depending on their comorbidity. The Charlson Index (ChI) and its adaptations are well established and widely used tools to quantify a patient comorbidity. The aim of this study is to evaluate the influence of comorbidity quantified by the ChI ...

journal_title：Medicina clinica

authors： Fácila Rubio L,Núñez Villota J,Bertomeu González V,Sanchís Fores J,Bodi Peris V,Consuegra Sánchez L,Sanjuán Mañez R,Llácer Escorihuela A

更新日期：2005-04-02 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The aim of the present study was to investigate the factors influencing CRP serum levels in the diabetic population. PATIENTS AND METHOD:Eighty-six patients with type 2 diabetes mellitus were prospectively included. The following variables were considered: age, gender, smoking habit, body mass...

journal_title：Medicina clinica

authors： Francisco G,Hernández C,Chacón P,Mesa J,Simó R

更新日期：2005-03-12 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We aimed to determine whether measuring the hyperacute lipid profile helps to start a cholesterol-lowering therapy soon after an ischemic stroke. PATIENTS AND METHOD:72 ischemic stroke patients underwent lipid determinations at three times (hyperacute phase or arrival, second day and the third...

journal_title：Medicina clinica

authors： Delgado Martínez P,Montaner Villalonga J,Chacón P,Purro F,Ribó M,Alvarez-Sabín J

更新日期：2005-03-05 00:00:00

abstract：:We describe the experience of the Maxillofacial Surgery Service of the Gregorio Maranon University Hospital in attending the victims of the terrorist attack of 11 March, 2004 in Madrid. The most important types of cranio-maxillofacial injury treated that day, their mechanisms of production, and the organization of the...

journal_title：Medicina clinica

authors： Navarro Vila C,Acero Sanz J,Barrios Robredo JM,Cuesta Gil M,López Atalaya FJ,Salmerón Escobar JI,Verdaguer Martín JJ

更新日期：2005-03-01 00:00:00

abstract：:In the present article we describe the activity of the admissions service on the day of the terrorist attacks, 11 March, 2004. Firstly, we try to describe the objectives and lines of intervention that we believe should be covered by our service. Subsequently, we describe how we organized ourselves into teams in order ...

journal_title：Medicina clinica

authors： Vicario D,Oria M,Hernández Sampelayo A,Quintanilla M

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Rounded atelectasis (RA) is an unusual form of pulmonary lesion often confounded with pulmonary neoplasia. We studied the main diagnostic and evolutive characteristics of a series of patients diagnosed with RA. PATIENTS AND METHOD:Twenty patients diagnosed of RA in a tertiary hospital in Catal...

journal_title：Medicina clinica

authors： Gispert P,Andreu J,Ferrer M,Ferrer J

更新日期：2005-02-26 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Our purpose was to provide information about static and dynamic balance posturographic disorders in elderly people with recurrent falls, and to compare the results with a healthy elderly group. PATIENTS AND METHOD:We included 95 subjects: 57 patients who fell (86% women; age, 78.1 years) and 3...

journal_title：Medicina clinica

authors： Lázaro M,Cuesta F,León A,Sánchez C,Feijoo R,Montiel M,Ribera JM

更新日期：2005-02-19 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Two different pathways for the development of tumor have been described in colorectal carcinoma: the chromosomic instability, raised by suppressor genes and proto-oncogene alterations, and the microsatellite instability (MSI), caused by alterations in DNA repairing genes. PATIENTS AND METHOD:T...

journal_title：Medicina clinica

authors： Vidaurreta M,Sanz-Casla MT,Maestro ML,Rafael S,Jiménez F,Arroyo M,Fernández C,Cerdán J

更新日期：2005-02-05 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Among nosocomial infections, pneumonia is one of the most important ones due to the mortality, morbidity and the increase of costs that it causes. The implementation of a cost-effective surveillance system for these infections is a challenge for hospitals. The objective of this work was to eval...

journal_title：Medicina clinica

authors： Bautista Rentero D,Giménez Ferri JL,Zanón Viguer V

更新日期：2005-01-22 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The PROCES (Programa de Reanimació Cardiopulmonar Orientat a Centres d'Ensenyament Secundari) program is aimed at teaching basic cardiopulmonary resuscitation (b-CPR) to teenagers within high school. Our aim was to analyze the results obtained from the pilot program. SUBJECTS AND METHOD:PROCES...

journal_title：Medicina clinica

authors： Miró O,Jiménez-Fábrega X,Díaz N,Coll-Vinent B,Bragulat E,Jiménez S,Espinosa G,Hernández-Rodríguez J,García-Alfranca F,Alvarez MT,Salvador J,Millá J,Sánchez M

更新日期：2005-01-15 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Infliximab is a chimeric monoclonal antibody that binds to tumor necrosis factor alpha and blocks the inflammatory response. The purpose of this study was to assess the effects of infliximab in patients with severe and refractory psoriasis. PATIENTS AND METHOD:Eleven patients with severe and r...

journal_title：Medicina clinica

authors： Mahiques Santos L,Martínez-Menchón T,Sánchez Carazo JL,Oliver Martínez V,Soriano Navarro CJ,Fortea Baixauli JM

更新日期：2004-11-13 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We decided to assess the overall prevalence of exposure to environmental tobacco smoke (ETS) both in general and according to the settings of exposure (home, workplace and leisure time). SUBJECTS AND METHOD:We analyzed cross-sectional data of ETS exposure in 1,059 non-smokers included in the C...

journal_title：Medicina clinica

authors： Twose J,Schiaffino A,García M,Martí M,Fernández E,Investigadores del Estudio de Seguimiento de la Encuesta de Salud de Cornellà (ES-ESC).

更新日期：2004-10-16 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Growth hormone binding protein (GHBP), insuline-like growth factor 1 (IGF-1) and insuline-like growth factor binding protein 3 (IGFBP-3) serum concentrations were studied in familial short-statured patients (FSS) and age-matched normal-statured subjects. The aim of the study was to ascertain wh...

journal_title：Medicina clinica

authors： del Valle Núñez CJ,López-Siguero JP,López-Canti LF,Lechuga Campoy JL,Espigares Martín R,Martínez-Aedo Ollero MJ,Grupo Andaluz de Endocrinología Pediátrica.

更新日期：2004-10-09 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The proportion of elderly patients hospitalized in acute care wards has progressively increased. Patients with a decreased functional status are prone to have malnutrition which negatively affects their prognosis and increases mortality. However, it is unclear whether functional and nutritional...

journal_title：Medicina clinica

authors： Asensio A,Ramos A,Núñez S

更新日期：2004-09-25 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The association between the presence of the allele APOE*epsilon4 (apolipoprotein E) and sporadic Alzheimer disease (AD) has been long established. However, the possible influence of other genetic factors is still under debate. This study investigated the role of the a 1-antichymotrypsin (ACT) g...

journal_title：Medicina clinica

authors： Hernández-Charro B,Moreno S,Valiente A,Manubens JM,Villar MD,Ramos-Arroyo MA

更新日期：2004-09-04 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Due to recent medical advances, patients with cystic fibrosis (CF) can expect longer survival rates and, as a result, face previously unreported complications such as osteoporosis. Our goal was to determine the mineral bone density in young adult patients with CF attended in the adult CF Unit, ...

journal_title：Medicina clinica

authors： Girón RM,Sánchez Moliní P,Almonacid C,Jiménez I,Rodríguez Salvanés F,García Vadillo A,Quintana ML,Hurtado J,Ancochea J

更新日期：2004-06-19 00:00:00

abstract：BACKGROUND AND OBJECTIVE:To describe the evolution of food, energy and nutritional consumption at preconception, weeks 6, 10, 26 and 38 of pregnancy, and 6 and 26 weeks after birth. SUBJECTS AND METHOD:Longitudinal evaluation of the nutritional status in 80 healthy volunteers with the intention of immediate conception...

journal_title：Medicina clinica

authors： Arija V,Cucó G,Vila J,Iranzo R,Fernández-Ballart J

更新日期：2004-06-05 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Our goal was to analyze the epidemiological and clinical findings, as well as the diagnostic approach in a group of patients in whom uveitis was the first manifestation of sarcoidosis. PATIENTS AND METHOD:Retrospective study (between March 1998 and July 2002) including 31 patients diagnosed wi...

journal_title：Medicina clinica

authors： Adán A,Baget M,De Llobet JM,Segura A,Marieges MT,Casaroli-Marano R

更新日期：2004-05-22 00:00:00

abstract：:Molecular techniques have allowed the identification of new viruses in a number of patients with cryptogenic hepatitis. Whether they are clinically inapparent or true hepatitis agents remains unknown for some of them. Latest described viruses include GBV, TTV and SENV. However, based on the limited data available, the...

journal_title：Medicina clinica

authors： Quirós-Roldán E,Torti C,Carosi G

更新日期：2004-04-17 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Burden of disease (DALYs) can help define health priorities. Our objective was to assess DALYs of those illnesses most important in Spanish children and teenagers. MATERIAL AND METHOD:We calculated DALYs components (YLL, YLD) by age groups and sex. Sources used were Spanish mortality data and ...

journal_title：Medicina clinica

authors： Cortés García M,Pereira Candel J,Peña-Rey Lorenzo I,Gènova Maleras R,Amela Heras C

更新日期：2004-03-20 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Parkinsonism is a group of neurological disorders characterized by extrapiramidal signs. Often, the differential diagnosis between parkinsonism, essential tremor and drug-induced parkinsonism is difficult. The aim of the study was to evaluate the utility of (123I)-FP-CIT SPECT in patients with ...

journal_title：Medicina clinica

authors： Lorenzo Bosquet C,Miquel Rodríguez F,Roca Bielsa I,Milà M,Aguadé Bruix S,Castell Conesa J

更新日期：2004-03-13 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Forced respiratory volume in first second spirometry is currently used to diagnose chronic obstructive pulmonary disease. However, this technique does not always provide a reliable short-term prognosis, especially in patients with associated morbidity. We propose that specific health-related qu...

journal_title：Medicina clinica

authors： Vega Reyes JA,Montero Pérez-Barquero M,Sánchez Guijo P

更新日期：2004-03-06 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The description of different forms of PSA has opened a new strategy in the diagnosis of prostate cancer. The measurement of the ratio between free PSA and PSA in the group of patients with a PSA level between 4 and 10 ng/ml decreases the number of negative biopsies. The aim of our study was to ...

journal_title：Medicina clinica

authors： Filella X,Truan D,Alcover J,Molina R,Luque P,Coca F,Ballesta AM

更新日期：2004-02-28 00:00:00

abstract：BACKGROUND AND OBJECTIVE:More information is needed on hypertension control in clinical practice, which includes taking at least two blood pressure (BP) readings and taking into account surgery times and previous antihypertensive drug intake. Our study aimed to assess the optimum degree of BP control in a broad sample ...

journal_title：Medicina clinica

authors： Llisterri Caro JL,Rodríguez Roca GC,Alonso Moreno FJ,Lou Arnal S,Divisón Garrote JA,Santos Rodríguez JA,Raber Béjar A,de Castellar Sansó R,Ruilope Urioste LM,Banegas Banegas JR,Grupo de Trabajo de Hipertension Arterial de la Sociedad

更新日期：2004-02-14 00:00:00

abstract：:Monitoring biomedical signals obtained from a patient generates information that processed conveniently, it has to allow detecting as soon as possible changes in the predicted evolution. The systematic register of one of these biomedical signals is named a time series. In this paper, a brief introduction appears to th...

journal_title：Medicina clinica

authors： Muñoz Gracia MP

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The treatment of biliary tract infections requires antibiotics and an appropriate surgical procedure. The aim of this study was to evaluate the efficacy and safety of piperacillin/tazobactam versus ceftriaxone plus ornidazole in the treatment of biliary tract infections. PATIENTS AND METHOD:Th...

journal_title：Medicina clinica

authors： Sirvent JM,Rodríguez JI,Rodríguez I,García-Oria M,Roig J,Bonet A

更新日期：2003-12-06 00:00:00

abstract：:Epidemiological research has consistently shown that physical activity decreases the risk of coronary heart disease, hypertension and stroke. The finding that a low level of physical activity is a major determinant of the growing epidemics of obesity is also firm and consistent. The direct association existing between...

journal_title：Medicina clinica

authors： Varo Cenarruzabeitia JJ,Martínez Hernández JA,Martínez-González MA

更新日期：2003-11-15 00:00:00

abstract：:Coronary heart disease is one of the major causes of death in developed countries. The hypothesis that peroxidation of low density lipoproteins (LDL) may be the initial step of the atherosclerotic process has promoted numerous studies aimed at investigating the mechanisms by which the body protects itself from such ox...

journal_title：Medicina clinica

authors： Canales A,Sánchez-Muniz FJ

更新日期：2003-10-25 00:00:00

abstract：BACKGROUND AND OBJECTIVE:For the treatment of obesity, an adecuate control of associated cardiovascular risk factors (CRF) is fundamental. The objective of this study was to assess the relationship between body mass index (BMI) and CRF, and the effect of a weight loss program on overweight subjects. PATIENTS AND METHO...

journal_title：Medicina clinica

authors： Bautista-Castaño I,Molina-Cabrillana J,Montoya-Alonso JA,Serra-Majem L

更新日期：2003-10-18 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Highly active antiretroviral therapy (HAART) has been considered to be ineffective in controlling hepatitis C viremia in the first year of treatment. The present study evaluates the effect of prolonged HAART upon HCV-VL. PATIENTS AND METHOD:We selected those cases with positive serology for HC...

journal_title：Medicina clinica

authors： Tornero C,Gimeno C,Igual R,Santamaría A,Gil E,Rull S

更新日期：2003-10-04 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) are excellent predictive factors of tissue damage, inflammation and infection. However, there is not sufficient data about their usefulness in elderly patients with acute septic pathology. Our objective was to identify the cytokines related ...

journal_title：Medicina clinica

authors： Martí L,Moreno A,Filella X,Marín JL,Almela M,Benito N,Sánchez M,Gatell JM

更新日期：2003-09-27 00:00:00

abstract：BACKGROUND AND OBJECTIVE:We aimed to know the prevalence of classical cardiovascular risk factors, hyperinsulinism, insulin resistance and metabolic syndrome (MS) in a population with coronary heart disease (CHD) as compared with a population without personal or familial history of cardiovascular risk factors. SUBJECT...

journal_title：Medicina clinica

authors： Hernández Mijares A,Riera Fortuny C,Solá Izquierdo E,Oliver Oliver MJ,Martínez Triguero ML,Morillas Ariño C,Morales Suárez-Varela M

更新日期：2003-07-12 00:00:00